Monitor Closely (1)crofelemer boosts levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Crofelemer has the potential to inhibit CYP3A4 at concentrations anticipated inside the intestine; not likely to inhibit systemically since minimally absorbed.
enasidenib will enhance the stage or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Enasidenib (a weak CYP2C19 inhibitor) may possibly maximize systemic exposure of delicate CYP2C19 substrates. Keep an eye on and change dose of substrate as clinically indicated.
topiramate will lower the extent or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Muscle spasms; convulsions brought on by epilepsy or fever; anxiety; agitation or insomnia affiliated with panic; panic assaults; for a pre-med ahead of operation or professional medical methods; along with other therapies in alcohol withdrawal
You're alarmed by how frequently the seizures happen, by how severe the seizure is, by how long the seizure lasts, or by the colour or respiratory of the individual.
armodafinil will lower the extent or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
nevirapine will lower the extent or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
diazepam will raise the amount or outcome of lemborexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Decrease nightly dose of lemborexant encouraged if coadministered with weak CYP3A4 inhibitors. See drug monograph for more info precise dosage modification.
eslicarbazepine acetate will enhance the level or result of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of.
VALTOCO is usually a federally controlled compound (CIV) because it is usually abused or result in dependence. Maintain VALTOCO in a safe position to avoid misuse and abuse.
Drugs which have constraints aside from prior authorization, quantity boundaries, and stage therapy related to Each individual prescription.
istradefylline will improve the amount or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
VALTOCO may perhaps harm your unborn infant. Are breastfeeding or intend to breastfeed. VALTOCO passes into your breast milk and could damage your little one. Speak with your Health care company about The ultimate way to feed your infant if you use VALTOCO. Explain to your Health care supplier about the many medicines you are taking, such as prescription and in excess of-the-counter medicines, natural vitamins, and herbal nutritional supplements.
VALTOCO comes in an easy-to-carry package that will go along with you any place VALTOCO suits within your pocket or a small bag Ready to use